Cyclin D2-CDK4 Complex Regulates Cell Cycle Progression (P16173)

Target Name: Cyclin D2-CDK4 complex

NCBI ID: P16173

Other Name(s): None

Cyclin D2-CDK4 Complex Regulates Cell Cycle Progression

The Cyclin D2-CDK4 complex is a protein complex that plays a crucial role in the regulation of cell cycle progression in humans. It is composed of the cyclin D2 protein, which is a key component of the G1 phase of the cell cycle, and the CDK4 protein, which is a key regulator of the G1/S phase transition.

The Cyclin D2-CDK4 complex is involved in the regulation of various cellular processes, including cell growth, differentiation, and division. It is also involved in the regulation of the cell cycle, which is the process by which a cell grows, replicates its DNA, and divides.

The Cyclin D2-CDK4 complex is made up of several different proteins, including cyclin D2, CDK4, p21, p53, and Rb. These proteins work together to regulate the different stages of the cell cycle.

One of the key functions of the Cyclin D2-CDK4 complex is to regulate the transition from the G1 phase to the S phase of the cell cycle. This is a critical step in the cell cycle, as it is during this stage that the cell prepares for cell division.

In the G1 phase, the Cyclin D2 protein helps to keep the cell's DNA in a closed state, which is necessary for cell growth and replication. The CDK4 protein, on the other hand, helps to regulate the G1/S phase transition by activating the G1-S transition protein, which allows the cell to transition from the G1 phase to the S phase.

Another important function of the Cyclin D2-CDK4 complex is to regulate the regulation of the cell cycle. This is the process by which the cell decides when to enter the S phase and when to exit the G1 phase. The Cyclin D2-CDK4 complex is involved in this regulation by the protein p21, which is a tumor suppressor protein that helps to prevent the cell from entering the S phase.

The Cyclin D2-CDK4 complex is also involved in the regulation of cell growth and differentiation. This is the process by which the cell develops into different types of cells and tissues. The Cyclin D2-CDK4 complex helps to regulate this process by controlling the activity of the protein p53, which is a tumor suppressor protein that helps to prevent the cell from growing too large.

In addition to its role in cell cycle regulation, the Cyclin D2-CDK4 complex is also involved in the regulation of DNA replication. This is the process by which the cell makes a copy of its DNA before it divides. The Cyclin D2-CDK4 complex is involved in this regulation by the protein Rb, which is a tumor suppressor protein that helps to prevent the cell from dividing too often.

The Cyclin D2-CDK4 complex is also involved in the regulation of cell survival. This is the process by which the cell decides when to live and when to die. The Cyclin D2-CDK4 complex helps to regulate this process by controlling the activity of the protein p53, which is a tumor suppressor protein that helps to prevent the cell from living too long.

In conclusion, the Cyclin D2-CDK4 complex is a protein complex that plays a crucial role in the regulation of cell cycle progression in humans. It is involved in the regulation of various cellular processes, including cell growth, differentiation, and division, as well as the regulation of the cell cycle, DNA replication, and cell survival. The Cyclin D2-CDK4 complex is a potential drug target or biomarker for various diseases, including cancer.

Protein Name: Cyclin D2-CDK4 Complex

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